Vimseltinib
Catalog No.
C8709
An orally available, highly selective CSF1R tyrosine kinase inhibitor
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Vimseltinib (DCC‑3014) is an orally available, highly selective CSF1R tyrosine kinase inhibitor featuring a “switch‑control” design. It binds to the regulatory region of the CSF1R kinase domain, stabilizing it in an inactive conformation, thereby blocking CSF‑1/IL‑34–induced autophosphorylation and downstream signaling such as ERK and AKT. CSF1R is a key receptor for the survival and differentiation of monocytes and macrophages, and is highly active in tenosynovial giant cell tumor and in some tumors enriched with tumor‑associated macrophages (TAM). Vimseltinib can eliminate CSF1R‑dependent pathological macrophages, reduce lesions, and improve symptoms.
| Storage | Store at -20°C |
| M.Wt | 431.5 |
| Cas No. | 1628606-05-2 |
| Formula | C23H25N7O2 |
| Synonyms | DCC-3014 |
| Chemical Name | 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one |
| SDF | Download SDF |
| Canonical SMILES | CC(C)NC1=NC=C(C(=O)N1C)C1=NC(C)=C(OC2=CC(=NC=C2)C2=CN(C)N=C2)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |