Tosufloxacin p-Toluenesulfonate Hydrate

Tosufloxacin p-Toluenesulfonate Hydrate (CAS No.: 1400591-39-0) is a synthetic small molecule fluoroquinolone class antibacterial research reagent, typically categorized within anti infective pharmacology and microbial susceptibility assay tool compounds, with broad activity reported across Gram positive and Gram negative bacterial systems and a primary functional background in studies of bacterial DNA topology control through inhibition of type II topoisomerase enzymes, principally DNA gyrase and topoisomerase IV, leading to disruption of DNA replication and transcription dynamics in susceptible strains; in biomedical research and early drug discovery workflows, this agent is commonly applied as a reference comparator for quinolone scaffold benchmarking, resistance mechanism profiling, and structure activity relationship guided optimization of antibacterial chemotypes, while pathway level interpretation generally centers on bacterial DNA damage stress responses and downstream effects on replication dependent cellular viability rather than host directed signaling modules; consistent with fluoroquinolone class behavior, reported in vitro potency is generally discussed in the nanomolar to micromolar range depending on organism, strain specific resistance determinants, and assay conditions, and experimental use in cell based microbiology platforms, infection related mechanistic models, and preclinical animal pharmacology paradigms is typically defined by protocol dependent concentration or dose selection, exposure duration, and study endpoints, with the concentrations or doses used in experiments typically depending on specific experimental designs and research objectives, and all use should remain restricted to controlled laboratory research settings only.