Thieno-GTP

Thieno-GTP is a modified guanosine triphosphate nucleotide in which the purine ring of guanine is substituted with a thiophene group, significantly altering the nucleotide's chemical properties and biological functions. Thieno-GTP can be incorporated into RNA molecules during in vitro transcription reactions, generating RNA containing thiophene modifications. Such chemically modified RNAs play an important role in studying RNA structure, function, and interactions with proteins. Due to the distinct chemical properties of the thiophene group, Thieno-GTP-modified RNAs are extensively utilized in labeling and detection applications. Additionally, this modification enhances the stability and translational efficiency of RNA, providing crucial applications in gene expression studies and the development of RNA-based therapeutics.