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TCS JNK 5a JNK2 and JNK3 inhibitor

Catalog No.B3275
Size Price Stock Qty
10mM (in 1mL DMSO)
$88.00
In stock
Evaluation Sample
$28.00
In stock
10mg
$68.00
In stock
25mg
$136.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

TCS JNK 5a

Biological Activity

Description TCS JNK 5a(JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 6.5, respectively.
Targets JNK3 JNK2        
IC50 (pIC50=6.5) (pIC50=6.7)        

TCS JNK 5a Dilution Calculator

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Chemical Properties

Cas No. 312917-14-9 SDF Download SDF
Chemical Name N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
Canonical SMILES C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N
Formula C20H16N2OS M.Wt 332.42
Solubility >16.6mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 7.5, respectively [1].

c-Jun N-terminal kinases (JNK) belong to the mitogen-activated protein kinase (MAPK) family. JNK1 and JNK2 are widely expressed, whereas JNK3 is mainly expressed in the brain and plays an important role to mediate neurodegeneration such as Alzheimer’s Disease and Parkinson’s Disease [1].

TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0 [1].

Reference:
[1].  Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett, 2007, 17(5): 1296-1301.