Sulfathiazole sodium

Sulfathiazole sodium (CAS No.: 144-74-1) is a short-acting sulfonamide antibiotic that mainly blocks bacterial dihydrofolate synthesis by inhibiting dihydropteroate synthase (DHPS), thereby interfering with bacterial nucleic acid and protein synthesis to inhibit bacterial growth. In in vitro studies, Sulfathiazole sodium shows antibacterial activity against a variety of Gram-positive and Gram-negative bacteria, with minimum inhibitory concentrations (MICs) typically in the low micromolar to micromolar range; specific values depend on the bacterial species and experimental conditions. In cell and animal models, Sulfathiazole sodium is commonly used to study the therapeutic effects on bacterial infections, and the doses or concentrations used in experiments usually depend on the experimental design and research objectives.