Sufugolix
Catalog No.
A9034
An orally active non-peptide LHRH receptor antagonist for reproductive endocrinology research.
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Sufugolix (TAK-013) is a non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with oral bioavailability. By specifically binding to pituitary LHRH receptors, it inhibits the release of gonadotropins, with an IC50 for the LHRH receptor of approximately 0.1 nM. This compound is commonly used in reproductive endocrinology research to investigate physiological mechanisms related to the LHRH pathway and to evaluate potential therapeutic strategies for hormone-dependent pathological conditions in preclinical models.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 667.73 |
| Cas No. | 308831-61-0 |
| Formula | C36H31F2N5O4S |
| Synonyms | TAK-013 |
| Solubility | Soluble in DMSO |
| Chemical Name | 1-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea |
| Canonical SMILES | O=C(C(C(CN(C)CC1=CC=CC=C1)=C(C2=CC=C(NC(NOC)=O)C=C2)S3)=C3N4CC5=C(F)C=CC=C5F)N(C6=CC=CC=C6)C4=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |