Sodium Dehydrocholate

Sodium Dehydrocholate (CAS No.: 145-41-5) is a semisynthetic bile acid salt derived from cholic acid and is broadly categorized as a hydrocholeretic research molecule used in hepatobiliary and gastrointestinal pharmacology, where it serves as a tool compound to investigate bile formation dynamics, biliary lipid transport, and bile acid load adaptation in preclinical systems; available evidence indicates that its primary functional background involves enhancement of bile output and stimulation of biliary lipid secretion, with reported modulation of autophagy associated processes and reductions in experimental serum amylase and lipase readouts in pancreatic injury related models, supporting mechanistic study of bile acid regulated metabolic and stress response networks, including hepatobiliary secretory function, cholesterol handling, and pancreas liver axis biology under obstructive or inflammatory conditions; although a single high affinity molecular target with standardized binding constants is not consistently defined for this compound, it is generally investigated at pathway and phenotype levels in bile acid signaling and digestive enzyme associated injury paradigms, and when quantitative potency metrics such as IC50 or EC50 are not established in standardized assay formats, activity is typically interpreted through concentration dependent cellular or physiological responses in low micromolar to millimolar experimental ranges depending on model context; in biomedical research and early drug discovery workflows, Sodium Dehydrocholate is commonly applied in cell based studies of hepatocyte or cholangiocyte secretory responses, as well as in animal models of cholestatic stress, biliary obstruction, or acute biliary pancreatitis related injury, while screening and translationally oriented pharmacology programs use it to benchmark hydrocholeretic like phenotypes and bile acid flux endpoints, and the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.