SN50

SN50 (CAS No.: 213546-53-3) is a synthetic, cell-permeable peptide inhibitor that selectively blocks the nuclear translocation of the transcription factor NF-κB, a central regulator of gene expression involved in inflammation, immune responses, and cell proliferation. By interfering with the intracellular transport of NF-κB from the cytoplasm to the nucleus, SN50 effectively suppresses NF-κB–mediated transcriptional activation and downstream signaling pathways, making it a valuable tool for dissecting NF-κB-dependent molecular mechanisms. This compound is widely utilized in studies investigating inflammatory signaling cascades, oncogenic processes, and immune modulation, particularly in cell-based assays and experimental models designed to evaluate pathway-specific responses. Its inhibitory activity is typically observed in the micromolar concentration range, although effective concentrations may vary depending on cell type and experimental conditions. SN50 is frequently employed in mechanistic studies, pathway validation, and early-stage drug discovery efforts targeting NF-κB-associated signaling networks, with dosing and exposure parameters tailored to specific research objectives.