Siramesine
Siramesine（Lu 28-179）is a specific agonist of sigma (σ) receptor [1].
Siramesine（Lu 28-179）has been reported to specific bind to σ2 receptor in human cortical and rat brain homogenates with Kd values of 1.1±0.2nM, 2.2 ±0.4nM and moderate capacity Bmax values of 26±3 fmol mg tissue-1,50±12 fmol mg tissue-1, respectively. In addition, Siramesine has shown the ligand selectivity profile of [3H]Lu28-179 binding to rat and human brain membranes with Ki values of 4.4±1.7nM and 8.6±0.6 nM, respectively. Apart from these, Siramesine has been revealed to displace [3H]DTG binding with very high affinity and [3H](+)pentazocine binding of σ2-sites. The IC50 of Siramesine inhibited the [3H]DTG binding is 0.19nM [1].
References:
[1] Søby KK1, Mikkelsen JD, Meier E, Thomsen C. Lu 28-179 labels a sigma(2)-site in rat and human brain. Neuropharmacology. 2002 Jul;43(1):95-100.
| Storage | Store at -20°C |
| M.Wt | 454.58 |
| Cas No. | 147817-50-3 |
| Formula | C30H31FN2O |
| Solubility | Soluble in DMSO |
| Chemical Name | 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine] |
| Canonical SMILES | Fc(cc1)ccc1-[n]1c(cccc2)c2c(CCCCN(CC2)CCC22OCc3c2cccc3)c1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
