Sacubitril metabolite-13C4

Sacubitril metabolite-13C4 is a stable isotope-labeled compound of Sacubitril. Sacubitril is a prodrug that is metabolized in vivo to generate the active metabolite LBQ657, which enhances the effects of endogenous natriuretic peptides by inhibiting neprilysin, thereby exerting biological effects such as vasodilation, diuresis, and blood pressure reduction. In biomedical research, Sacubitril metabolite-13C4, as an isotope-labeled compound, is mainly used for pharmacokinetic and metabolism studies. Leveraging its isotopic properties, it enables precise tracking of Sacubitril’s metabolic pathways and rates in vivo via mass spectrometry analysis. Because its chemical properties are similar to those of the unlabeled Sacubitril metabolite, the dose or concentration used in experiments typically depends on the experimental design and research objectives. In cell and animal models, Sacubitril metabolite-13C4 is commonly used to evaluate a drug’s absorption, distribution, metabolism, and excretion characteristics, providing important scientific evidence for new drug development and clinical application.