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S-(5'-Adenosyl)-L-methionine (sulfate tosylate)

Catalog No.
C3530
A universal methyl donor cofactor involved in transmethylation reactions and methylation homeostasis.
Grouped product items
Size Price Stock Qty
1mL(10 mM in H2O)
$88.00
In stock
50mg
$78.00
In stock
100mg
$98.00
In stock
500mg
$315.00
In stock
1g
$529.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

S-(5'-Adenosyl)-L-methionine (sulfate tosylate) (CAS No.: 52248-03-0) is a biologically important compound widely recognized as a universal methyl donor, playing a role in numerous biochemical processes mediated by DNA and protein methyltransferases. As part of a methyl donor and cofactor system, this compound is essential for various cellular mechanisms, such as epigenetic regulation, post-translational modification of proteins, and metabolic pathways. Originating from natural biological processes, it serves as a precursor molecule in transmethylation reactions and is particularly important for maintaining cellular methylation homeostasis. S-(5'-Adenosyl)-L-methionine is commonly used in biomedical research contexts, with particular attention to its antiproliferative, pro-apoptotic, and antimetastatic activities in cancer research. Its in vitro activity is typically in the nanomolar to micromolar range, depending on experimental conditions and research objectives. Commonly used in studies involving cell models and animal models, this compound has significant research value for understanding its potential roles in cancer biology, hepatocyte function, and joint pathology, with concentrations typically adjusted according to experimental purposes. As an important research tool, it helps explore complex signaling networks and biological interactions that underlie various physiological and pathological states.

Chemical Properties

Physical AppearanceA lyophilized powder
Storage-20°C
M.Wt570.64
Cas No.52248-03-0
FormulaC22H30N6O8S2
SynonymsAdoMet; SAM; SAMe
Solubility≤1mg/ml in methanol;5mg/ml in water
Chemical Name((R)-3-amino-3-carboxypropyl)(((2R,3R,4S,5S)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium 4-methylbenzenesulfonate
Canonical SMILESO[C@@H]1[C@@H]([C@H](O[C@H]1C[S+](CC[C@H](C(O)=O)N)C)N2C=NC3=C2N=CN=C3N)O.CC4=CC=C(C=C4)S(=O)([O-])=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

S-(5'-Adenosyl)-L-methionine (sulfate tosylate)
 

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