Retigabine-d4
Catalog No.
SL1071
A stable isotope deuterated compound of Retigabine
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Retigabine-d4 (CAS No.: 1781825-04-4) is a stable isotope-labeled form of the antiepileptic drug retigabine (Retigabine). Retigabine exerts anticonvulsant effects by activating KCNQ2-5 voltage-gated potassium channels in neurons. In in vitro studies, retigabine shows an EC50 of approximately 1.6 μM for KCNQ2/3 channels, indicating low micromolar activity. In cellular and animal models, retigabine can reduce the frequency and severity of seizures by enhancing GABAergic transmission and stabilizing neuronal membrane potential. As an isotope-labeled compound, Retigabine-d4 is mainly used for pharmacokinetic and metabolism studies, helping scientists track the metabolic pathways and distribution of retigabine in biological systems. The dose or concentration used in experiments typically depends on the experimental design and research objectives.
| Storage | Store at -20°C |
| M.Wt | 307.36 |
| Cas No. | 1781825-04-4 |
| Formula | C16H14D4FN3O2 |
| Chemical Name | ethyl (2-amino-4-(fluorobenzylamino)phenyl)carbamate |
| SDF | Download SDF |
| Canonical SMILES | N(C(OCC)=O)C1=C(N)C=C(NCC2=C(C(=C(F)C(=C2[2H])[2H])[2H])[2H])C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |