Resmetirom
Catalog No.
B8918
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Resmetirom (CAS 920509-32-6), also known as MGL-3196, is a selective agonist of the thyroid hormone receptor-beta (THR-β). By specifically activating THR-β, resmetirom modulates lipid metabolism pathways and hepatic lipid homeostasis. Preclinical and clinical investigations have explored its therapeutic potential in metabolic disorders characterized by dyslipidemia and hepatic steatosis. Resmetirom has been studied extensively in the clinical context of non-alcoholic steatohepatitis (NASH) and heterozygous familial hypercholesterolemia, reflecting its relevance in metabolic disease research.
| Storage | Store at -20°C |
| M.Wt | 435.22 |
| Cas No. | 920509-32-6 |
| Formula | C17H12Cl2N6O4 |
| Synonyms | MGL-3196; VIA-3196 |
| Solubility | ≥61.7 mg/mL in DMSO; ≥3.18 mg/mL in EtOH with gentle warming; insoluble in H2O |
| Chemical Name | 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | CC(C)C1=CC(Oc(c(Cl)cc(N(C(NC2=O)=O)N=C2C#N)c2)c2Cl)=NNC1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
