Raloxifene HCl
Raloxifene HCl（LY139481）is a potent and selective of estrogen receptor (ER) with the IC50 value of 2.9~5.7nM [1].
Raloxifene HCl（LY139481）is a selective and uncompetitive of estrogen receptor (ER) with the IC50 value of 2.9~5.7nM for phthalazine oxidase in human liver cytosol. In addition, Raloxifene has been found to be a potent inhibitor for the three oxidation reactions with the Ki values of 0.87nM, 1.2nM and 1.4nM for phthalazine oxidation, vanillin oxidation and nicotine-△1’(5‘)-iminium ion oxidation, respectively. And the inhibition of Raloxifene HCl is not time-dependent fashion. Apart from these, Raloxifene HCl has been reported to noncompetitively inhibit the aldehyde oxidase-catalyzed reduction reaction with the Ki value of 52nM [1].
References:
[1] Obach RS.Potent inhibition of human liver aldehyde oxidase by raloxifene.
Drug Metab Dispos. 2004 Jan;32(1):89-97.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 510.04 |
| Cas No. | 82640-04-8 |
| Formula | C28H28ClNO4S |
| Solubility | ≥22.35 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
