Quetiapine-d8 Hemifumarate (piperazine-d8)
Catalog No.
SL1040
A stable isotope deuterated compound of Quetiapine Hemifumarate
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Quetiapine-d8 Hemifumarate (piperazine-d8) is the stable isotope-labeled counterpart of Quetiapine Hemifumarate, mainly used in drug metabolism and pharmacokinetic studies in biomedical research. As an atypical antipsychotic, Quetiapine Hemifumarate has a mechanism of action involving modulation of multiple neurotransmitter receptors, including agonist activity at the 5-HT1A receptor (pEC50 approximately 4.77) and antagonist activity at the D2 receptor (pIC50 approximately 6.33), and it also shows moderate to high affinity for receptors such as 5-HT2A and 5-HT2C. In in vitro studies, Quetiapine Hemifumarate exhibits activity in the nanomolar to low micromolar range. In cell and animal models, Quetiapine-d8 Hemifumarate can be used as an internal standard for drug metabolism studies, and the dose or concentration used typically depends on the experimental design and research objectives.
| Storage | Store at -20°C |
| M.Wt | 449.59 |
| Cas No. | 1435938-24-1 |
| Formula | C21D8H17N3O2S·0.5(C4H4O4) |
| Chemical Name | 2-(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethoxy)ethan-1-ol fumarate |
| SDF | Download SDF |
| Canonical SMILES | OC(/C=C/C(O)=O)=O.OCCOCCN1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])C2=NC3=CC=CC=C3SC4=CC=CC=C24 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |