Quetiapine-d8 fumarate

Quetiapine-d8 fumarate is the stable isotope-labeled counterpart of Quetiapine fumarate, mainly used in drug metabolism studies and quantitative analysis in biomedical research. As an atypical antipsychotic, Quetiapine exerts its therapeutic effects primarily by antagonizing dopamine D1, D2, and D3 receptors, as well as multiple neurotransmitter receptors such as serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors. In in vitro studies, Quetiapine typically shows binding affinities to these receptors in the nanomolar to micromolar range. In cell and animal models, Quetiapine-d8 fumarate is often used as an internal standard to improve the accuracy and sensitivity of liquid chromatography-mass spectrometry (LC-MS) analysis. The dose or concentration used in experiments typically depends on the experimental design and research objectives.