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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Psicofuranine is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (XMP) aminase with IC50 value of 67 μM [1][2][3].
Xanthosine 5’-phosphate (XMP) aminase is an enzyme essential for guanine nucleotide synthesis and possess catalytic activity with either glutamine or ammonia as a substrate [2][3].
Psicofuranine (9-n-psicofuranosy-6-aminopurine) is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (XMP) aminase with IC50 value of 67 μM. In unfractionated preparations of both strains B-24 and B-35-2, 6.7 X 10-5M psicofuranin inhibited 50% XMP aminase after 2 minutes. Psicofuranine caused a guanine deficiency in enteric bacteria by inhibition of XMP aminase [2]. Psicofuranine-inhibited aminase couldn’t catalyze the aminolysis of the preformed intermediate to AMP and GMP, nor could it condense ATP and XMP to form the intermediate [3]. Psicofuranine had good antibacterial activity in vivo and antitumor activity [1].
References:[1]. Ladislav J. Hanka. MECHANISM OF ACTION OF PSICOFURANINE. J Bacteriol. 1960 Jul; 80(1): 30–36.[2]. UDAKA S, MOYED HS. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803.[3]. Fukuyama TT. Formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine. J Biol Chem. 1966 Oct 25;241(20):4745-9.
