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Psicofuranine

Catalog No.
C5775
inhibitor of xanthosine monophosphate (XMP) aminase
Grouped product items
SizePriceStock Qty
1mg
$104.00
Ship with 5-10 days
5mg
$437.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Psicofuranine is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (XMP) aminase with IC50 value of 67 μM [1][2][3].

Xanthosine 5’-phosphate (XMP) aminase is an enzyme essential for guanine nucleotide synthesis and possess catalytic activity with either glutamine or ammonia as a substrate [2][3].

Psicofuranine (9-n-psicofuranosy-6-aminopurine) is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (XMP) aminase with IC50 value of 67 μM. In unfractionated preparations of both strains B-24 and B-35-2, 6.7 X 10-5M psicofuranin inhibited 50% XMP aminase after 2 minutes. Psicofuranine caused a guanine deficiency in enteric bacteria by inhibition of XMP aminase [2]. Psicofuranine-inhibited aminase couldn’t catalyze the aminolysis of the preformed intermediate to AMP and GMP, nor could it condense ATP and XMP to form the intermediate [3]. Psicofuranine had good antibacterial activity in vivo and antitumor activity [1].

References:
[1].  Ladislav J. Hanka. MECHANISM OF ACTION OF PSICOFURANINE. J Bacteriol. 1960 Jul; 80(1): 30–36.
[2].  UDAKA S, MOYED HS. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803.
[3].  Fukuyama TT. Formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine. J Biol Chem. 1966 Oct 25;241(20):4745-9.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt297.3
Cas No.1874-54-0
FormulaC11H15N5O5
SynonymsAngustmycin C,NSC 53104
SolubilitySoluble in DMSO
Chemical Name1'-C-(hydroxymethyl)-adenosine
SDFDownload SDF
Canonical SMILESOC[[email protected]@H]1[[email protected]@H](O)[[email protected]@H](O)[[email protected]@](N2C=NC3=C2N=CN=C3N)(CO)O1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Psicofuranine