PNU-282987 S enantiomer free base

PNU-282987 S enantiomer free base (CAS No.: 737727-12-7) is the stereochemically defined S-enantiomer of PNU-282987, a synthetic small molecule belonging to the class of quinuclidine benzamide derivatives that function as selective agonists of the α7 nicotinic acetylcholine receptor (α7 nAChR), a ligand-gated ion channel widely expressed in neuronal and non-neuronal tissues. By selectively activating α7 nAChRs, this compound modulates cholinergic neurotransmission and downstream signaling pathways, including calcium influx and intracellular cascades associated with synaptic plasticity, neuroinflammation, and neurotransmitter release. In vitro studies of PNU-282987 and related analogs have demonstrated functional activity typically in the nanomolar to low micromolar range, supporting its utility as a pharmacological probe for receptor activation and subtype selectivity investigations. The S-enantiomer is of particular interest in stereochemical and structure–activity relationship studies aimed at understanding enantioselective receptor binding and functional outcomes. This compound is commonly employed in cellular assays, electrophysiological studies, and preclinical experimental models to investigate α7 nAChR-mediated mechanisms, with concentrations or dosing regimens adjusted according to specific experimental designs and research objectives in neuroscience, neuropharmacology, and receptor biology.