NXY-059
NXY-059 is a newly synthesized used in the treatment of ischaemic stroke [1].
NXY-059 has shown a significant differences in arterial Po2 and pH between the experimental groups before ischemia in BBB permeability study with Po2 value of 112.9±9.7mm Hg and pH value of 7.443±0.01. In addition, in rats, NXY-059 has been reported to significantly improve neurologic deficits at 24 hours when given at 6 hours of reperfusion. Besides, treatment with NXY-059 has been revealed to significantly ameliorate the brain damage. Thereby, the mean volumes of infarct and total damage are reduced to 9.2±14.8%（P<0.05） and 10.9±15.8%(P<0.01), respectively [1].
References:
[1] Kuroda S1, Tsuchidate R, Smith ML, Maples KR, Siesjö BK.
Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 1999 Jul;19(7):778-87.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 381.33 |
| Cas No. | 168021-79-2 |
| Formula | C11H13NNa2O7S2 |
| Solubility | Soluble in DMSO |
| Chemical Name | disodium;4-[(Z)-[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)[N+](=CC1=C(C=C(C=C1)S(=O)(=O)[O-])S(=O)(=O)[O-])[O-].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | NXY-059 is a novel nitrone with efficacious neuroprotective effects. | |||||
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| IC50 | ||||||
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
