NVP-2
NVP-2 (CAS No.: 1263373-43-8) is a highly potent and selective ATP-competitive inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation through its association with cyclin T. By targeting the CDK9/CycT complex with sub-nanomolar potency, NVP-2 effectively suppresses RNA polymerase II–mediated transcription, thereby modulating gene expression programs critical for cell survival and proliferation. In addition to its primary activity, NVP-2 exhibits weaker inhibitory effects against related kinases such as CDK1/CycB, CDK2/CycA, and CDK16/CycY in the micromolar range, indicating a high degree of selectivity for CDK9. Functionally, inhibition of CDK9 by NVP-2 leads to rapid transcriptional repression and induction of apoptosis in sensitive cell types, making it a valuable chemical probe for studying transcriptional regulation, oncogenic signaling, and dependency on transcriptional machinery in cancer and other diseases. This compound is widely utilized in cell-based assays and mechanistic studies to investigate CDK9-driven pathways, and its application in experimental systems typically depends on specific study designs and biological contexts.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 513.07 |
| Cas No. | 1263373-43-8 |
| Formula | C27H37ClN6O2 |
| Solubility | ≥46.1 mg/mL in DMSO |
| Chemical Name | 4-(((5'-chloro-2'-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile |
| Canonical SMILES | ClC1=CN=C(N[C@@H]2CC[C@@H](N[C@H](C)COC)CC2)C=C1C3=CC=CC(NCC4(C#N)CCOCC4)=N3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
