Nifurtimox

Nifurtimox (CAS No.: 23256-30-6) is a nitrofuran antiprotozoal drug, mainly used to treat Chagas disease caused by Trypanosoma cruzi and African human trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense. Its mechanism of action involves the generation of reactive oxygen free radicals, leading to parasite DNA damage and cell death. In vitro studies show that Nifurtimox inhibits Trypanosoma cruzi at low micromolar levels. In cell and animal models, Nifurtimox is often used to evaluate its antiparasitic activity and potential antitumor effects; the doses or concentrations used in experiments typically depend on the experimental design and research objectives.