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Nifuratel

Catalog No.
A3659
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Antibacterial, antifungal, and antiprotozoal compound
Grouped product items
SizePriceStock Qty
10mg
$65.00
Ship with 10-15 days
50mg
$104.00
Ship with 10-15 days
100mg
$126.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Description: IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1] Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp. in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1]. in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2]. Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3]. Clinical trial: N/A

Chemical Properties

StorageStore at -20°C
M.Wt285.28
Cas No.4936-47-4
FormulaC10H11N3O5S
SynonymsNF 113;SAP 113;Methylmercadone
SolubilitySoluble in DMSO
Chemical Name5-(methylsulfanylmethyl)-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
SDFDownload SDF
Canonical SMILESCSCC1CN(C(=O)O1)N=CC2=CC=C(O2)[N+](=O)[O-]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:

Cell lines

Atopobium vaginae, G. vaginalis, Lactobacillus

Preparation method

The solubility of this compound in DMSO is soluble. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0.125 μg/ml-0.5 μg/ml

Applications

In vitro, nifuratel is able to inhibit the growth of Atopobium vaginae with a MIC range of 0.125-1 μg / mL. It is active against G.vaginalis and does not affect lactobacillus. These observations suggested that nifuratel may be the most effective treatment for bacterial vaginosis.

References:

[1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40. doi: 10.2174/157488412799218824. PMID: 22082330; PMCID: PMC3362959.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Nifuratel