NIBR189
Catalog No.
B8010
EBI2 (GPR183) receptor antagonist
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NIBR189 (CAS 1599432-08-2) is a small molecule antagonist targeting Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183), a G protein-coupled receptor implicated in immune cell migration and localization. NIBR189 displays high affinity antagonism at EBI2, inhibiting receptor function with an IC50 of 16 nM in binding assays and 11 nM in functional assays. By modulating EBI2-mediated signaling pathways, NIBR189 serves as a useful tool in biomedical investigations focused on immunity, inflammation, and related disease models.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 429.31 |
| Cas No. | 1599432-08-2 |
| Formula | C21H21BrN2O3 |
| Solubility | ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one |
| SDF | Download SDF |
| Canonical SMILES | BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
