MMRi62
Catalog No.
BA2833
MMRi62 is an iron death inducer that targets (oncogene p53 negative regulator).
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MMRi62 is an iron death inducer targeting (negative regulator of the oncogene p53).MMRi62 displays p53-independent pro-apoptotic activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells.MMRi62 induces iron death accompanied by an increase in reactive oxygen species and lysosomal degradation of the ferritin heavy chain.MMRi62 also results in the proteasome of mutant p53 degradation and has in vivo efficacy in an in situ xenograft PDAC mouse model characterized by high-frequency mutations in KRAS and TP53.
| Physical Appearance | A solid |
| Storage | 4°C, protect from light |
| M.Wt | 396.27 |
| Cas No. | 352693-80-2 |
| Formula | C21H15Cl2N3O |
| Solubility | ≥50.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |