Mibefradil
Catalog No.
A3604
Calcium channel blocker
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Mibefradil (CAS 116644-53-2) is a calcium channel antagonist exhibiting preferential inhibition of T-type calcium channels. It demonstrates moderate selectivity with reported IC50 values of approximately 2.7 μM for T-type Ca2? channels and 18.6 μM for L-type channels, thus predominantly targeting low-voltage activated calcium currents. Due to its mechanism of action, mibefradil has clinical relevance in cardiovascular research and is utilized experimentally for investigating T-type calcium channel involvement in hypertension and chronic angina pectoris.
| Storage | Store at -20°C |
| M.Wt | 495.63 |
| Cas No. | 116644-53-2 |
| Formula | C29H38FN3O3 |
| Synonyms | Ro 40-5967 |
| Solubility | ≥49.6 mg/mL in DMSO; ≥53.4 mg/mL in EtOH with gentle warming; ≥96.8 mg/mL in H2O with gentle warming |
| Chemical Name | 2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate |
| SDF | Download SDF |
| Canonical SMILES | CC(C1C2=C(C=C(F)C=C2)CCC1(OC(COC)=O)CCN(CCCC3=NC4=CC=CC=C4N3)C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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