Lolamicin

Lolamicin is a Gram-negative specific antibiotic.Lolamicin is active against more than 130 multidrug-resistant clinical isolates, has shown efficacy in several mouse models of acute pneumonia and sepsis infections, and protects the gut microbiome of mice against secondary infections with Clostridium difficile.The selective killing of pathogenic Gram-negative bacteria by Lolamicin is a result of low sequence homology between pathogenic The selective killing of pathogenic Gram-negative bacteria by Lolamicin is the result of low sequence homology between pathogenic bacteria and commensal bacteria.Lolamicin can be used in the study of infections caused by Gram-negative pathogens.