LEE011 hydrochloride

LEE011 hydrochloride (CAS No.: 1211443-80-9) is a highly selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, mainly used to inhibit cell cycle progression and block the transition of cells from the G1 phase to the S phase, thereby inhibiting cell proliferation. Its half-maximal inhibitory concentrations (IC50) for CDK4 and CDK6 are 10 nM and 39 nM, respectively, demonstrating potent nanomolar inhibitory activity. In in vitro studies, LEE011 hydrochloride can significantly inhibit the proliferation of multiple tumor cell lines and is commonly used to evaluate the potential of CDK4/6 inhibitors in cancer therapy. In animal models, its antitumor activity is typically evaluated via oral administration, and the doses or concentrations used in experiments usually depend on the experimental design and research objectives. This compound has important research value in drug screening and anticancer drug development.