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KN-92

Catalog No.
A3529
CaMKII inhibitor
Grouped product items
SizePriceStock Qty
5mg
$257.00
In stock
10mg
$355.00
In stock
50mg
$936.00
In stock
200mg
$2,149.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

KN-92 is an inactive derivative of KN-93. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.

Product Citation

Chemical Properties

Physical AppearanceA yellow oil
StorageStore at -20°C
M.Wt456.98
Cas No.176708-42-2
FormulaC24H25ClN2O3S
SynonymsKN 92;KN92
Solubilityinsoluble in H2O; ≥15.1 mg/mL in DMSO; ≥24.2 mg/mL in EtOH with gentle warming
Chemical Name(E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide
SDFDownload SDF
Canonical SMILESCN(CC1=CC=CC=C1NS(=O)(C2=CC=C(OC)C=C2)=O)C/C=C/C3=CC=C(Cl)C=C3
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

KN-92