JKE-1674
Catalog No.
BA3406
JKE-1674 is an orally active glutathione peroxidase 4 inhibitor and is an active metabolite of an inhibitor ML-210.
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JKE-1674 is an orally active glutathione peroxidase 4 inhibitor that is the active metabolite of an inhibitor ML-210.JKE-1674 is an analog of ML-210 in which the nitroisoxazole ring is replaced by an alpha-nitroketoxime.JKE-1674 can be converted to the nitrile oxide JKE-1777.JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 killed LOX-IMVI cells in the same manner as ML-210 and was completely rescued by an inhibitor.
| Physical Appearance | A solid |
| Storage | 4°C, protect from light |
| M.Wt | 451.30 |
| Cas No. | 2421119-60-8 |
| Formula | C20H20Cl2N4O4 |
| Solubility | ≥50.6 mg/mL in DMSO; ≥8.6 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one |
| SDF | Download SDF |
| Canonical SMILES | O=[N+]([O-])C/C(C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)=O)=N\O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
