Jingzhaotoxin III
Catalog No.
B5763
NaV1.5 channels blocker
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Jingzhaotoxin III (CAS 925463-91-8) is a selective inhibitor of the voltage-gated sodium channel Nav1.5, a protein primarily expressed in cardiac myocytes and crucial for cardiac electrophysiological activity. Jingzhaotoxin III blocks Nav1.5 channels with an IC50 of approximately 0.348 μM, demonstrating a rapid-onset and reversible inhibition that is concentration-dependent, showing complete inhibition at 1.03 μM. Animal studies indicate its capability to reduce both frequency and severity of arrhythmias, suggesting its utility in cardiac arrhythmia research and associated therapeutic exploration.
| Physical Appearance | White lyophilised solid |
| Storage | Store at -20°C |
| M.Wt | 3919.47 |
| Cas No. | 925463-91-8 |
| Formula | C174H241N47O46S6 |
| Solubility | Soluble to 1 mg/ml in H2O |
| Chemical Name | 1-((1Z,4Z,7Z,10Z)-9-(2-carboxyethyl)-1,4,7,10-tetrahydroxy-6-isopropyl-3,12-dimethyl-1-((12E,15E,18E,21E,24Z,27Z,30Z,33Z,36Z,39Z,42E,50E,53E,56E,59E,62E,65Z,68Z,71Z,74Z,77Z,80Z,83Z,91E,93Z)-29,32,76,82-tetrakis((1H-indol-3-yl)methyl)-44-((E)-(2-((Z)-(2-(( |
| SDF | Download SDF |
| Canonical SMILES | CC(C(/N=C(O)/C(/N=C(O)/C1CSSCC(N=C(O)C2CCCN2C(C3CCCN34)=O)/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/5)C)CC6=CC=C(O)C=C6)CCCCN)CSSCC(/N=C(O)\C(/N=C(O)/C/N=C(O)/C(N)CC(O)=O)CCC(O)=O)/C(O)=N\C/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity ≥95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
