Isavuconazonium sulfate

Isavuconazonium sulfate (CAS No.: 946075-13-4) is a synthetic small molecule and triazole class antifungal research reagent that serves as a prodrug of isavuconazole and is widely used in biomedical investigations of fungal biology, host pathogen interactions, and anti infective discovery pipelines, where its functional background is defined by rapid bioconversion through plasma esterase activity to the active azole moiety that inhibits fungal lanosterol 14 alpha demethylase CYP51 in the ergosterol biosynthesis pathway, thereby reducing ergosterol production, destabilizing fungal membrane architecture, increasing membrane permeability, and promoting loss of intracellular components with consequent growth inhibition and fungal cell death in susceptible species; in vitro potency reported across fungal panels is commonly described in the nanomolar to micromolar range depending on organism, strain susceptibility, assay medium, and exposure duration, and in research practice it is applied in susceptibility profiling, resistance mechanism studies, combination screening with other antifungal classes, and translational pharmacology experiments in cell based infection systems and animal models of invasive mycoses, while the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives, including pathogen burden, endpoint selection, and pharmacokinetic exposure targets.