ISA-2011B

ISA-2011B (CAS No.: 1395347-24-6) is a synthetic small-molecule lipid kinase inhibitor that specifically targets phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5K1α), an enzyme that catalyzes the production of phosphatidylinositol 4,5-bisphosphate (PI4,5P2), thereby regulating the membrane phosphatidylinositol pool, cytoskeletal organization, and proximal signal transduction; by limiting the availability of PI4,5P2, ISA-2011B can perturb downstream pathways associated with PIP5K1α activity, including PI3K–AKT signaling, PLC-dependent calcium dynamics, and actin remodeling, and has shown measurable antiproliferative effects and apoptosis-inducing characteristics in in vitro prostate cancer cell models. Reported activity is generally in the low micromolar range, with specific potency depending on the assay method, cellular context, and readout. In biomedical research and drug development, ISA-2011B is commonly used as a probe compound to dissect phosphatidylinositol signaling networks, validate the target role of PIP5K1α in tumor biology, and support mechanism elucidation, target occupancy and binding assessment, as well as combination or control screening with related pathway modulators; typical applications include treatment of cultured cell systems and exploratory early-stage model studies to evaluate pathway dependence and phenotypic outcomes, while the concentrations or doses used in experiments typically depend on the specific experimental design and research objectives. This product is for laboratory research use only and is not intended for human or veterinary use, clinical applications, consumption, or any non-research purpose.