Ingenol-3-angelate
Ingenol-3-angelate (CAS No.: 75567-37-2) is a hydrophobic diterpene ester isolated from the Euphorbiaceae plant Euphorbia peplus. It has attracted attention as a protein kinase C (PKC) modulator, showing potent regulatory potential toward the α, β, γ, δ, and ε isoforms of PKC, with significant nanomolar activity. This compound induces rapid death of proliferative keratinocytes by affecting cell membranes and mitochondria, and can trigger apoptosis in certain cancer cell lines, demonstrating antitumor and anti-inflammatory activity mainly in in vitro and preclinical studies. In experimental settings, this compound is used in cell models and preliminary drug screening, with the concentrations or doses typically determined according to the specific experimental design and research objectives. The ability of Ingenol-3-angelate to reduce actinic keratosis under experimental conditions demonstrates its value in studying skin-related diseases at the cellular level, providing strong support for further exploration of signaling pathways in inflammatory and proliferative diseases.
| Physical Appearance | A crystalline solid |
| Storage | -20°C |
| M.Wt | 430.53 |
| Cas No. | 75567-37-2 |
| Formula | C25H34O6 |
| Synonyms | Ingenol Mebutate; 3- Ingenyl Angelate; PEP005; Picato |
| Solubility | ≤10mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide |
| Chemical Name | (Z)-(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-6-yl 2-methylbut-2-enoate |
| Canonical SMILES | CC([C@@H]1OC(/C(C)=C\C)=O)=C[C@@]23[C@]1(O)[C@H](O)C(CO)=C[C@]([C@@]4([H])[C@@](C4(C)C)([H])C[C@H]3C)([H])C2=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |