IDO inhibitor 1
Catalog No.
A3483
Indoleamine-2,3-dioxygenase inhibitor
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IDO inhibitor 1 is a potent and novel indoleamine-2,3 dioxygenase (IDO) inhibitor with IC50 value <100 nM.
IDO is an enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine and permits tumor cells to escape the immune system.
Reference:
[1]. Andrew P. Combs, et al. 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase. Patent Numeber: EP 2315756 A2
http://www. google.com/patents/EP2315756A2?cl=en
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 438.23 |
| Cas No. | 1204669-37-3 |
| Formula | C11H13BrFN7O4S |
| Solubility | insoluble in H2O; ≥19.35 mg/mL in DMSO; ≥34.75 mg/mL in EtOH with ultrasonic |
| Chemical Name | (E)-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide |
| SDF | Download SDF |
| Canonical SMILES | NS(NCCNc1n[o]nc1/C(\NO)=N\c(cc1)cc(Br)c1F)(=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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