IBMX
Catalog No.
B7206
Phosphodiesterase inhibitor
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IBMX (CAS 28822-58-4) is a methylxanthine derivative commonly employed in research as a non-selective inhibitor of phosphodiesterase (PDE) isozymes. It inhibits PDE3, PDE4, and PDE5 with IC50 values of approximately 6.5, 26.3, and 31.7 μM, respectively. By inhibiting PDE activity, IBMX elevates intracellular cyclic AMP (cAMP) and cyclic GMP (cGMP) concentrations, thereby activating downstream cyclic nucleotide-dependent protein kinases. Additionally, IBMX antagonizes adenosine receptors, blocking endogenous adenosine-mediated cellular effects. In animal studies, IBMX administration has been shown to modulate drug-induced behavioral sensitization, highlighting its utility in neuropharmacological research.
- 1. Zimengwei Ye, Yi Zhao, et al. "Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells." Front Pharmacol. 2024 Aug 14:15:1386794 PMID: 39206264
- 2. Meiping Zhang, Xueling Yue, et al. "Dipeptidyl peptidase‐4 disturbs adipocyte differentiation via the negative regulation of the glucagon‐like peptide‐1/adiponectin‐cathepsin K axis in mice under." FASEB J. 2024 May 31;38(10):e23684. PMID: 38795334
- 3. Zhongyu Xie, et al. "TNF‐α‐Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy‐Related Protein VCP." Adv Sci (Weinh). 2024 Mar;11(10):e2303388. PMID: 38145956
- 4. Fang YX, Zou Y, et al. "lnc TINCR induced by NOD1 mediates inflammatory response in 3T3-L1 adipocytes." Gene. 2019 May 25;698:150-156. PMID: 30851423
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 222.24 |
| Cas No. | 28822-58-4 |
| Formula | C10H14N4O2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥9.45 mg/mL in DMSO |
| Chemical Name | 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C(N(C)C1=O)N(C2=C1NC=N2)CC(C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
