HJC0152 HCl

HJC0152 HCl (CAS No.: 1420290-99-8) is a synthetic small molecule classified as a selective chemical probe for research on transcription factor signal transduction and tumor biology, derived from niclosamide-inspired molecular optimization to improve water solubility and experimental applicability in preclinical systems; mechanistically, as an inhibitor of signal transducer and activator of transcription 3 (STAT3), it reduces intracellular total STAT3 and phosphorylation levels and limits its nuclear translocation, thereby attenuating STAT3-driven transcriptional programs and the activity of related downstream pathways; in in vitro studies, this compound has shown antiproliferative effects in representative human cell models (such as triple-negative and luminal breast, pancreatic, and head and neck squamous cell-derived models), with activity typically observed at low micromolar levels, accompanied by G0/G1 cell-cycle arrest and apoptosis under appropriate experimental conditions; for in vivo proof-of-concept, it has been used in mouse xenograft and orthotopic models to explore STAT3 dependency and tumor growth-related phenotypes, with administration routes and regimens determined by controlled experimental design; typical applications include target validation, pathway mapping, mechanistic studies based on reporter gene or imaging readouts, and use as a reference compound in phenotypic or targeted screening, with the specific concentration or dose used in experiments depending on the research objective and experimental design; this product is intended only for scientific research by qualified personnel in a laboratory setting and must not be used for human or veterinary purposes, diagnosis, clinical use, or any consumer-related applications.