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Helioxanthin 8-1

Catalog No.
B4701
inhibitor of HBV and HIV virus
Grouped product items
SizePriceStock Qty
2mg
$368.00
Ship with 10-15 days
5mg
$551.00
Ship with 10-15 days
10mg
$788.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Helioxanthin 8-1, an analogue of helioxanthin (ACH126447), is an inhibitor of HBV and HIV virus with EC50 values of 0.03 μM and 2.7 μM, respectively [1].

Helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with EC50 values of 0.03 μM and 2.7 μM for HBV and HIV, respectively [1]. In the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis B virus (DHBV) DNA synthesis with a mean IC50 value of 0.25±0.05 μM. Besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with CC50 values of 18±2 μM and 45±3 μM, respectively, by using an MTT assay [2].

References:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2] Ying C1, Tan S, Cheng YC.  Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.

Chemical Properties

StorageStore at -20°C
M.Wt376.32
Cas No.840529-13-7
FormulaC20H12N2O6
SolubilitySoluble in DMSO
Chemical Name11-(benzo[d][1,3]dioxol-5-yl)-[1,3]dioxolo[4',5':3,4]benzo[1,2-g]phthalazine-7,10-diol
SDFDownload SDF
Canonical SMILESOC1=NN=C(O)C2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Helioxanthin 8-1