Foxy-5

Foxy-5(CAS 881188-51-8), a Wnt5a peptide mimetic with clear anti-cancer activity, can significantly enhance the adhesion ability of MDA-MB-468 breast cancer cells and effectively inhibit their migratory activity when used at concentrations ranging from 1 to 1000 μM. In a mouse xenograft model established with DU145-Luc cells, administration of this compound at a dose of 2 mg/kg significantly reduced the number of lymph node metastases; however, it did not show a significant effect on the growth of the primary tumor.

References：

[1] Säfholm A, Leandersson K, Dejmek J, Nielsen CK, Villoutreix BO, Andersson T. A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J Biol Chem. 2006 Feb 3;281(5):2740-9. doi: 10.1074/jbc.M508386200. Epub 2005 Dec 5. PMID: 16330545.

[2] Canesin G, Evans-Axelsson S, Hellsten R, Krzyzanowska A, Prasad CP, Bjartell A, Andersson T. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. doi: 10.1371/journal.pone.0184418. PMID: 28886116; PMCID: PMC5590932.