Fenbufen
Catalog No.
B6127
COX inhibitor, non-steroidal anti-inflammatory drug
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Fenbufen (CAS No.: 36330-85-5) is a non-steroidal anti-inflammatory drug (NSAID), mainly used to relieve pain and inflammatory responses. Its mechanism of action primarily involves inhibiting cyclooxygenase (COX) activity and reducing prostaglandin synthesis, thereby exerting anti-inflammatory and analgesic effects. In vitro studies show that Fenbufen inhibits COX-1 and COX-2 with activities of 3.9 μM and 8.1 μM, respectively, in the low micromolar range. In addition, Fenbufen also exhibits inhibitory activity against caspase family proteins (including caspase-1, 3, 4, 5, 9). In cellular and animal models, Fenbufen is commonly used to study its anti-inflammatory and analgesic effects, and the doses or concentrations used in experiments typically depend on the experimental design and research objectives.
| Storage | Store at -20°C |
| M.Wt | 254.28 |
| Cas No. | 36330-85-5 |
| Formula | C16H14O3 |
| Solubility | ≥47.6 mg/mL in DMSO; ≥4.4 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | 4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(CCC(c(cc1)ccc1-c1ccccc1)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
