Estradiol 17-(β-D-Glucuronide) (sodium salt)
Catalog No.
C3840
substrate of the multidrug resistance protein 2 (MRP2)
Featured Products
Estradiol 17-(β-D-Glucuronide) (sodium salt) (CAS: 15087-02-2) is a glucuronide conjugate of estradiol that serves as a substrate for multidrug resistance protein 2 (MRP2), an ATP-binding cassette transporter localized at the hepatocyte apical membrane. MRP2 mediates ATP-dependent, osmotically-sensitive transport of this compound, as demonstrated in vitro using membrane vesicles from HeLa cells transfected with MRP2. In animal models, administration of estradiol 17-(β-D-Glucuronide) acutely inhibits bile flow and bile acid secretion, causing dose-dependent cholestasis reversible within hours. This compound represents a useful tool in investigating hepatic transport mechanisms and drug-induced cholestasis.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 470.5 |
| Cas No. | 15087-02-2 |
| Formula | C24H31O8·Na |
| Synonyms | E217G,β-Estradiol 17-(β-D-Glucuronide),17β-Estradiol 17-(β-D-Glucuronide),17β-Oestradiol 17-(β-D-Glucuronide) |
| Solubility | ≤20mg/ml in DMSO;10mg/ml in dimethyl formamide |
| Chemical Name | (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl β-D-glucopyranosiduronic acid, monosodium salt |
| SDF | Download SDF |
| Canonical SMILES | [H][C@@]12CCC3=CC(O)=CC=C3[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@@H]4O[C@@]5([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C([O-])=O)O5.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 99.64%
- COA (Certificate Of Analysis)
- HPLC
- MSDS (Material Safety Data Sheet)
Chemical structure
