Eicosapentaenoic Acid ethyl ester
Eicosapentaenoic Acid ethyl ester (CAS No.: 86227-47-6) is an important ω-3 fatty acid agent widely used in biomedical research and drug development, primarily focusing on lipid metabolism and related fields. As an esterified derivative of eicosapentaenoic acid, this compound plays an important role in regulating lipid metabolism pathways, with biological mechanisms including the enhancement of hepatic β-oxidation enzyme activity. In vitro studies have shown that, at low micromolar levels, it can improve hepatic β-oxidation enzyme activity and regulate triglyceride levels, and this has been validated in animal models, mainly by increasing the concentration of ω-3 fatty acids in hepatic triglycerides and phospholipids to regulate intrahepatic lipid content. Researchers often use this compound in research settings to investigate the physiological effects of ω-3 fatty acids on lipid profiles, with typical applications including evaluation in cell and animal models to determine its effects on hepatic triglyceride levels and fatty acid composition. The concentrations or doses used in experiments typically depend on the specific experimental design and research objectives. Eicosapentaenoic Acid ethyl ester is used as a tool for studying the fundamental biochemical processes of lipid metabolism disorders and does not involve direct clinical application.
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | -20°C |
| M.Wt | 330.5 |
| Cas No. | 86227-47-6 |
| Formula | C22H34O2 |
| Synonyms | E-EPA; EPA ethyl ester; Ethyl Eicosapentaenoate; C20:5 (5Z,8Z,11Z,14Z,17Z) ethyl ester; Icosapent ethyl; SFE 22:5 |
| Solubility | ≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide |
| Chemical Name | (5Z,8Z,11Z,14Z,17Z)-ethyl icosa-5,8,11,14,17-pentaenoate |
| Canonical SMILES | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCC)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |






