DSPE-PEG2000-Mal ammonium
DSPE-PEG2000-Mal ammonium (CAS No.: 474922-22-0) is a maleimide-terminated PEGylated phospholipid with amphiphilic properties,which can be incorporated into lipid assemblies and used for carrier surface functionalization. Its maleimide terminus can be conjugated to thiol-containing molecules, including appropriately functionalized peptides, proteins and antibody fragments. This reagent can be used to prepare ligand-functionalized liposomes, lipid nanoparticles and nanostructured lipid carriers for lipid carrier surface modification and cell-targeting studies, and can also be used to conjugate targeting ligands to the surfaces of mRNA-loaded nanoparticles.
References:
[1] Herrera-Barrera M, Ryals RC, Gautam M, Jozic A, Landry M, Korzun T, Gupta M, Acosta C, Stoddard J, Reynaga R, Tschetter W, Jacomino N, Taratula O, Sun C, Lauer AK, Neuringer M, Sahay G. Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci Adv. 2023 Jan 13;9(2):eadd4623. doi: 10.1126/sciadv.add4623. Epub 2023 Jan 11. PMID: 36630502; PMCID: PMC9833661.
[2] Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Adv Mater. 2024 Jun;36(26):e2313226. doi: 10.1002/adma.202313226. Epub 2024 Mar 15. PMID: 38419362; PMCID: PMC11209815.
| Storage | -20℃, sealed storage, away from moisture |
| M.Wt | 2000 (Average) |
| Cas No. | 474922-22-0 |
| Formula | (C2H4O)nC51H92NO13P.H3N |
| Synonyms | DSPE-PEG2000 Maleimide ammonium; DSPE-PEG2K-Mal ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium |
| Canonical SMILES | O=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCN1C(C=CC1=O)=O)=O.N.[n] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |







