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DSPE-PEG2000-Mal ammonium

Catalog No.
M2025
DSPE-PEG2K-Mal is a maleimide-terminated PEGylated phospholipid that can be conjugated to thiol-containing molecules and used to functionalize lipid carrier surfaces.
Grouped product items
Size Price Stock Qty
Evaluation Sample
$30.00
Ships within 10-15 days
1mg
$50.00
Ships within 10-15 days
2mg
$80.00
Ships within 10-15 days
5mg
$105.00
Ships within 10-15 days
10mg
$160.00
Ships within 10-15 days
25mg
$319.00
Ships within 10-15 days
50mg
$515.00
Ships within 10-15 days
100mg
$800.00
Ships within 10-15 days
250mg
$1,485.00
Ships within 10-15 days
500mg
$2,300.00
Ships within 10-15 days
1g
$3,780.00
Ships within 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

DSPE-PEG2000-Mal ammonium (CAS No.: 474922-22-0) is a maleimide-terminated PEGylated phospholipid with amphiphilic properties,which can be incorporated into lipid assemblies and used for carrier surface functionalization. Its maleimide terminus can be conjugated to thiol-containing molecules, including appropriately functionalized peptides, proteins and antibody fragments. This reagent can be used to prepare ligand-functionalized liposomes, lipid nanoparticles and nanostructured lipid carriers for lipid carrier surface modification and cell-targeting studies, and can also be used to conjugate targeting ligands to the surfaces of mRNA-loaded nanoparticles.

References:

[1] Herrera-Barrera M, Ryals RC, Gautam M, Jozic A, Landry M, Korzun T, Gupta M, Acosta C, Stoddard J, Reynaga R, Tschetter W, Jacomino N, Taratula O, Sun C, Lauer AK, Neuringer M, Sahay G. Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci Adv. 2023 Jan 13;9(2):eadd4623. doi: 10.1126/sciadv.add4623. Epub 2023 Jan 11. PMID: 36630502; PMCID: PMC9833661.

[2] Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Adv Mater. 2024 Jun;36(26):e2313226. doi: 10.1002/adma.202313226. Epub 2024 Mar 15. PMID: 38419362; PMCID: PMC11209815.

Chemical Properties

Storage-20℃, sealed storage, away from moisture
M.Wt2000 (Average)
Cas No.474922-22-0
Formula(C2H4O)nC51H92NO13P.H3N
SynonymsDSPE-PEG2000 Maleimide ammonium; DSPE-PEG2K-Mal ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium
Canonical SMILESO=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCN1C(C=CC1=O)=O)=O.N.[n]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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