Dotinurad

Dotinurad (CAS No.: 1285572-51-1) is a synthetic small molecule used in life sciences research as a selective urate reabsorption inhibitor and is primarily categorized as a transporter focused tool compound for studies of purine metabolism and renal urate handling, with reported activity against urate transporter 1 indicating potent inhibition in the nanomolar range in target specific assays and uricosuric related functional activity observed from nanomolar to micromolar range across assay contexts, supporting its use in mechanistic investigations of URAT1 mediated urate flux, proximal tubule transport biology, and pathway level analyses of uric acid homeostasis; in biomedical research and early drug discovery workflows, it is commonly applied to characterize transporter selectivity profiles, benchmark URAT1 focused screening platforms, and evaluate pharmacology in relevant cell based transport systems and preclinical animal models of altered urate balance, while experimental concentrations or study doses are selected according to model characteristics, assay sensitivity, and specific research objectives, and all use should be restricted to controlled laboratory research settings with no implication of clinical, dietary, or other non research applications.