Danicopan
Catalog No.
BA5882
Danicopan (ACH-4471) is a selective orally active inhibitor.
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Danicopan (ACH-4471) is a selective, orally active inhibitor with a high binding affinity for with a value of 0.54 nM.Danicopan (ACH-4471) inhibits the alternative pathway of complement (APC) activity and has the potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). potential to block the alternative pathway of complement.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 580.41 |
| Cas No. | 1903768-17-1 |
| Formula | C26H23BrFN7O3 |
| Synonyms | ACH-4471 |
| Solubility | ≥51 mg/mL in DMSO; ≥6.34 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=NC=C(C=N1)C2=CC(C(C(C)=O)=NN3CC(N4C[C@H](F)C[C@H]4C(NC5=NC(Br)=CC=C5)=O)=O)=C3C=C2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
