Colistin Methanesulfonate (sodium salt)
Colistin methanesulfonate (sodium salt; CAS 8068-28-8) is an inactive prodrug of colistin (polymyxin E), a polypeptide antibiotic derived from Paenibacillus polymyxa strains. It targets Gram-negative bacteria by disrupting the integrity of bacterial outer membranes, leading to bacterial cell death. In vitro analyses indicate concentration-dependent bactericidal activity against Pseudomonas aeruginosa, requiring significantly elevated levels above minimum inhibitory concentrations (MIC) for complete microbial eradication. It serves primarily as a tool compound for exploring antimicrobial mechanisms and resistance dynamics in Gram-negative pathogens.
| Storage | Store at -20°C |
| M.Wt | 1749.8 |
| Cas No. | 8068-28-8 |
| Formula | C58H105N16O28S5·5Na |
| Synonyms | Colimycin M,Polymyxin E sodium methanesulfonate |
| Solubility | ≥53.9 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO |
| Chemical Name | sodium (Z)-N-((6Z,9Z)-7,10-dihydroxy-8-(1-hydroxyethyl)-5-((Z)-oxido(((1Z,4E,7Z,10Z,13Z,16Z,19Z)-2,5,11,14-tetrahydroxy-3-(1-hydroxyethyl)-12,15-diisobutyl-8,17,20-trioxido-6,9,18-tris(2-((sulfomethyl)amino)ethyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1, |
| SDF | Download SDF |
| Canonical SMILES | CCC(CCCC/C([O-])=N/C(/C(O)=N/C(/C(O)=N/C(/C([O-])=N/C(/C([O-])=N/C(/C([O-])=N/C(/C(O)=N/C(/C(O)=N/C(/C([O-])=N/C(/C(O)=N\1)CCNCS(O)(=O)=O)CCNCS(O)(=O)=O)CC(C)C)CC(C)C)CCNCS(O)(=O)=O)CC/N=C(O)/C1C(O)C)CCNCS(O)(=O)=O)C(O)C)CCNCS(O)(=O)=O)C.[Na+].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
P. aeruginosa |
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Preparation method |
The solubility of this compound in H2O is ≥ 53.9mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
0.5～1mg/l |
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Applications |
Colistin methanesulfonate has a MIC range of 0.5 to 1 mg /l. In addition, by investigating among the mucoid and non-mucoid strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients, it was found that colistin methanesulfonate requires 16 times the MIC concentration to completely kill the bacteria within 24 hours. |
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References: [1]. Bozkurt-Guzel C, Gerceker AA. In vitro pharmacodynamic properties of colistin methanesulfonate and amikacin against Pseudomonas aeruginosa. Indian J Med Microbiol. 2012 Jan-Mar;30(1):34-8. PubMed PMID: 22361758. |
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Quality Control & MSDS
- View current batch:
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Potency ≥390 μg/mg
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
