cis-Δ2-11-methyl-Dodecenoic Acid

cis-Δ2-11-methyl-Dodecenoic Acid (CAS No.: 677354-23-3) is a biologically active quorum sensing signal molecule belonging to the diffusible signal factor family, which is secreted by bacteria and fungi to mediate extracellular communication and coordinate collective behaviors. This lipid-derived signaling mediator interacts with specific receptor systems to modulate downstream gene expression, thereby regulating key pathogenic processes such as virulence factor production, biofilm formation, and microbial adaptation within host environments. It has been widely utilized as a model compound for investigating quorum sensing pathways and host–pathogen interactions, particularly in studies of microbial pathogenicity and anti-infective strategy development. In vitro studies indicate that this compound exhibits high signaling potency, with activity detectable in the submicromolar to low micromolar range, demonstrating significantly greater efficacy compared to structurally related isomers and saturated analogs in biosensor-based assays. Mechanistically, it is implicated in DSF-mediated signaling cascades that influence transcriptional regulatory networks and intercellular communication in diverse microbial species. In research applications, cis-Δ2-11-methyl-Dodecenoic Acid is commonly employed in cell-based assays and microbial culture systems to dissect quorum sensing mechanisms, evaluate inhibitors of biofilm formation, and explore therapeutic strategies targeting bacterial communication pathways, with experimental concentrations typically adjusted according to specific assay conditions and study objectives.