Ciliobrevin A
Catalog No.
A8655
Hh pathway antagonist
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Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Peturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
| Physical Appearance | Yellow solid |
| Storage | Store at -20°C |
| M.Wt | 358.18 |
| Cas No. | 302803-72-1 |
| Formula | C17H9Cl2N3O2 |
| Solubility | Soluble in DMSO |
| Chemical Name | (2E)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)propanenitrile |
| SDF | Download SDF |
| Canonical SMILES | N#CC(C(c(ccc(Cl)c1)c1Cl)=O)=C(Nc1ccccc11)NC1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
