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CHR-6494

Catalog No.
A3309
Haspin inhibitor,potent ands selective
Grouped product items
SizePriceStock Qty
5mg
$80.00
Ship with 10-15 days
10mg
$150.00
Ship with 10-15 days
50mg
$449.00
Ship with 10-15 days
100mg
$760.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt292.34
Cas No.1333377-65-3
FormulaC16H16N6
SynonymsCHR 6494;CHR6494
SolubilitySoluble in DMSO
Chemical Name3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine
SDFDownload SDF
Canonical SMILESCCCNC1=NN2C(=NC=C2C3=CC4=C(C=C3)NN=C4)C=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

CHR-6494