Cephradine monohydrate

Cephradine monohydrate (CAS No.: 75975-70-1) is a small molecule, synthetic first generation beta lactam cephalosporin broadly classified as an antibacterial research reagent and pathway modulation probe, with primary relevance to microbiology, host pathogen interaction studies, and anti infective drug discovery workflows; as a cephalosporin class agent, its canonical mechanism involves inhibition of bacterial cell wall peptidoglycan biosynthesis through binding to penicillin binding proteins, leading to bactericidal effects across susceptible Gram positive and Gram negative organisms, while published preclinical findings also indicate direct inhibition of T lymphokine activated killer cell originated protein kinase as an additional activity linked to attenuation of ultraviolet induced inflammatory signaling in experimental skin systems, supporting use in both infection biology and inflammation related mechanistic research; reported antibacterial potency for this class is commonly evaluated by minimum inhibitory concentration profiling and is generally observed from low to moderate micromolar equivalent exposure ranges depending on strain background and resistance determinants, whereas kinase associated effects are typically characterized in biochemical or cell based assays within micromolar to submillimolar experimental windows when specific dataset conditions vary; in practice, this compound is used in bacterial susceptibility testing panels, resistance mechanism characterization, comparative benchmarking against other beta lactam scaffolds, and exploratory studies in cultured epithelial or immune relevant cell models and selected animal inflammation or infection models, with concentrations or doses used in experiments typically depending on specific experimental designs, model sensitivity, and study objectives.