Ceftezole sodium

Ceftezole sodium (CAS No.: 41136-22-5) is the sodium salt of ceftezole, a semi synthetic first generation cephalosporin derivative in the cephem class that is widely categorized as an antibacterial research tool for microbiology and anti infective discovery, with reported broad spectrum activity against many Gram positive and Gram negative bacteria and reduced or limited activity against selected species such as Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens, and its primary mechanistic framework is consistent with beta lactam mediated inhibition of bacterial cell wall biosynthesis through binding to penicillin binding proteins and disruption of peptidoglycan cross linking, while additional reports indicate alpha glucosidase inhibitory activity that supports its use in metabolism oriented enzymology studies as a secondary functional profile; in laboratory settings, potency readouts are generally interpreted through MIC based antibacterial assays and enzyme inhibition formats with activity often discussed at micromolar to sub millimolar exposure windows depending on strain background, enzyme source, and assay conditions, and because standardized cross platform values are not always directly comparable, concentration selection is typically optimized per protocol; accordingly, this molecule is commonly used in in vitro bacterial susceptibility panels, resistance mechanism investigations, target engagement studies involving cell wall associated proteins, and exploratory phenotypic or mechanism informed screening workflows, with additional use in cell based or animal research contexts for pharmacology and proof of concept interrogation where the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.